The project aims at an interdisciplinary approach to the development of new classes of inhibitors of voltage gated calcium channels (VGCCs) and the study of their properties in relation to chronic pain. The organic chemistry part focuses on the development of novel radical amination methodologies for the synthesis of small organic molecules with heterocyclic skeletons, and the elucidation of their mechanism. The resulting library will be studied with respect to the pharmacological activity of calcium ion channels and their in vivo analgesic properties.
The candidate holds a PhD degree in organic chemistry and has strong expertise in organic chemistry, is interested in methodology development and mechanism elucidation, can independently design and perform syntheses of complex molecules, develop synthetic methodology, has experience with all relevant analytical and lab techniques, and is able to analyze and summarize experimental data. The candidate collaborates and participates in group activities, is organized, self-motivated, and enthusiastic to be part of an organic chemistry project linked to drug discovery and can communicate and write proficiently in English.
We offer:
- Competitive financial remuneration (60.000 CZK gross salary)
- 5 weeks of vacation plus 4 days of personal leave
- Collaboration in an international team
- Further education and training
- Financial support for parents with young children who return to work immediately after the maternity/parental leave
- Health insurance and full benefits package incl. contribution to supplementary pension insurance, contribution to sports/culture/leisure time, meals subsidized by the employer, etc.
- Working in a young, promising, and progressive scientific team of biologists, medicinal chemists, virologists, immunologists, computational chemists, and biochemists
- State-of-the-art instrumentation portfolio
- Location in the stunning city of Prague
Additional information:
- Full-time fixed-term employment contract initially for 1 year with the potential of extension for another year
- Earliest start date: January 1st, 2025
How to apply:
Applications will be reviewed and considered until the position is filled. Suitable candidates will be contacted to arrange an interview. Please note that if you are not contacted within 6 weeks, we have given preference to candidates who more closely meet the criteria. Thank you for your understanding.
All applications should be sent to Dr. Emanuela Jahn at emanuela.jahn@uochb.cas.cz.
The application should consist of a cover letter pointing out your competence and experience with respect to the requirements of this position, CV, PhD degree certificate, publication list and contact information for two referees.
